Yeast as budding stem cells?
نویسندگان
چکیده
منابع مشابه
RNAi in budding yeast.
RNA interference (RNAi), a gene-silencing pathway triggered by double-stranded RNA, is conserved in diverse eukaryotic species but has been lost in the model budding yeast Saccharomyces cerevisiae. Here, we show that RNAi is present in other budding yeast species, including Saccharomyces castellii and Candida albicans. These species use noncanonical Dicer proteins to generate small interfering ...
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The highly orchestrated progression of the cell cycle depends on the degradation of many regulatory proteins at different cell cycle stages. One of the key cell cycle ubiquitin ligases is the Skp1-cullin-F-box (SCF) complex. Acting in concert with the substrate-binding F-box protein Grr1, SCF promotes the degradation of cell cycle regulators as well as various metabolic enzymes. Using a yeast t...
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It has been suggested that irreducible sets of states in Probabilistic Boolean Networks correspond to cellular phenotype. In this study, we identify such sets of states for each phase of the budding yeast cell cycle. We find that these "ergodic sets" underly the cyclin activity levels during each phase of the cell cycle. Our results compare to the observations made in several laboratory experim...
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ژورنال
عنوان ژورنال: Nature Structural & Molecular Biology
سال: 2009
ISSN: 1545-9993,1545-9985
DOI: 10.1038/nsmb0409-351